This seminar has been cancelled due to Hurricane Sandy. It will be rescheduled at a later date.
Technological advances in the development of fluorescent probes,solid-state imagers, and microscopy techniques have enabled biomolecularstudies at the single-molecular level. Fluorescent techniques use lightas an intermediary and rely on imagers for interfacing to thesolid-state. More intriguing are new electronic techniques forsingle-molecule detection based on charge. In particular, both nanoporesand nanotube field-effect transistors have demonstrated capabilities forsingle-molecule detection. Here, we review and discuss the potentialadvantages these direct solid-state interfaces bring to biophysics interms of transducer gain, signal-to-noise ratio, specificity and spatialresolution.